| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 19-4-25 19:45 | Austin FC | Los Angeles Galaxy | -:- |
| 19-4-25 22:30 | Columbus Crew | Inter Miami CF | -:- |
| 20-4-25 1:30 | Seattle Sounders | Nashville SC | -:- |
| 20-4-25 1:30 | New York Red Bulls | D.C. United | -:- |
| 20-4-25 1:30 | New England Revolution | New York City FC | -:- |
| 20-4-25 1:30 | Philadelphia Union | Atlanta United FC | -:- |
| 20-4-25 1:30 | CF Montreal | Orlando City | -:- |
| 20-4-25 1:30 | Charlotte FC | San Diego FC | -:- |
| 20-4-25 2:30 | St. Louis City SC | Vancouver Whitecaps | -:- |
| 20-4-25 2:30 | Minnesota United FC | FC Dallas | -:- |
| 20-4-25 2:30 | Houston Dynamo | Colorado Rapids | -:- |
| 20-4-25 2:30 | Chicago Fire | FC Cincinnati | -:- |
| 20-4-25 3:30 | Real Salt Lake | Toronto FC | -:- |
| 20-4-25 4:15 | Portland Timbers | Los Angeles FC | -:- |
| 20-4-25 4:30 | San Jose Earthquakes | Sporting Kansas City | -:- |